乳癌をはじめとした乳腺疾患専門の診療を行っています。
診断、手術、化学療法、放射線治療まで一貫した治療が可能です。
乳癌検診2次精査、セカンドオピニオン等も承っています。

※症状のない方の1次検診は当科では行っておりません。

※乳腺腫瘍センター・外来

病院の3階にあります。木の雰囲気を持った、温かみのある外来です。

・乳房温存手術

乳房を残したい方のために、積極的に乳房温存手術を行っています。
乳がん手術は乳房切除による徹底した局所制御が重要とされてきましたが、乳房の一部のみを切除し、残った乳房に放射線照射を行う乳房温存療法により、それと同様の効果が得られることが示されました。
腫瘍の状態によって異なりますが、必要な方には相談の上で術前化学療法も行っています。

・センチネルリンパ節生検

不要な腋窩リンパ節の郭清を避けるため、センチネルリンパ節生検を行っています。

これまで脇の下リンパ節の徹底した摘出（腋窩郭清）が行われてきましたが、リンパ節に転移がない場合も多く、腕が腫れるなどの合併症もあるため問題視されていました。
最近はリンパの流れが最初に到達し、最も転移の可能性があるリンパ節（センチネルリンパ節）を手術中に摘出して、そこに転移がなければ腋窩郭清を省略することが可能となりました。

・小線源による放射線治療

小線源用照射装置

通常、乳房温存手術を行った場合には乳房全体に放射線照射が必要であり、毎日5～6週間の照射を行うこととなります。
この治療は必要な治療ですが、通院に伴う負担や時間的負担、副作用も懸念されます。

当院では手術時に乳房内にアプリケーターを留置し、乳房内から局所照射を行うことでわずか手術後4日間で放射線照射を終了することが可能です。
通常手術後7日間程度の入院期間中に行うことが可能であり、乳房を残された患者さんの負担を大きく軽減出来ます。
小線源治療は口腔・舌・前立腺・食道がん・子宮頸部がん・肺がんなどに利用されていますが、欧米諸国では、乳がん治療にも広く活用されております。

乳癌手術実績

※累計（2008.8～2023.3）

外来化学療法症例

• 延べ1,485症例（2018年4月～2019年3月）

・放射線医学センター

PET/CT

マンモグラフィ

放射線照射装置

当院では放射線医学センターを有し、綿密な協力体制にて診療を行っております。
診断支援機能を有するマンモグラフィー、乳房超音波、乳房MRI、 PET/CTといった診断機器から放射線治療装置まで、最新の設備を備えています。

当放射線医学センターの特徴のひとつとして、「放射線治療」があります。
多くの他施設で使用している放射線照射装置「リニアック」では、周囲の正常な組織への副作用が多く発生することが課題になっています。
しかし、当院の最新リニアックは、照射位置を病巣のみにターゲットを絞ることができる、3Dリニアックを導入しており、放射線治療専門医が常駐しております。
この3Dリニアックでは、多方向からの照射を行ない、その重複する位置（病巣）に放射線が集中する画期的な装置で、誤差は約2mmとも言われています。

・化学療法センター

化学療法センター

治療用椅子

化学療法センター受付

抗癌剤点滴のための専門治療センターです。
乳癌の化学療法はほとんどが外来通院にて行うことが可能です。
安心して外来化学療法を受けていただくために、専任看護師・薬剤師による説明を行っています。
また、抗癌剤はすべて薬剤師により無菌調剤されており、安全管理に最大の注意をはらっています。

・手術室

熟練スタッフと、最新の手術室にて安全な手術を行います。

・病室

病棟デイルーム

個室病室

ほとんどの治療は外来で行うことが可能ですが、手術時等、入院が必要な際は快適な病室でお過ごしいただけます。

佐藤 一彦 主要論文業績（当院在籍以降）

1.〔邦文雑誌〕K Sato, H Takayanagi, Y Mizuno, M Kato. Open-cavity implant forAccelerated partial breast irradiation (APBI) using HDR multicatheterBrachytherapy. Rinsho Geka. 2011 ;66(13) :1669-1672.

2.〔邦文雑誌〕N Takeda, Y Mizuno, H Abe, Y Inoue, K Sato. Use of Cell Block toDetermine Treatment Options for a Patients with Metastatic Breast Cancer-a Case Report- Nippon Rinsho Geka Gakkai Zasshi. 2013;74:2714-2717

3.〔邦文雑誌〕M Iwai, H Fuchikami, Y Mizuno, N Takeda, H Seto, T Kudo, K Sato.Factors Affecting Adherence of Patients with Breast Cancer to AdjuvantHormonal Therapy Along with Validation of the Evaluation MethodJpn J Cancer Chemother 2014;417:843-847

4.〔邦文雑誌〕H Fuchikami, Y Mizuno, N Takeda, K Sato. A case of breast cancer with internal jugular vein occlusion that was improved after intravenous Stenting. -a Case Report- Nippon Rinsho Geka Gakkai Zasshi.2015;76:2387-2391

5.〔邦文雑誌〕N Takeda, H Fuchikami, Y Inoue, K Sato. A case of inflammatory breast cancer detected as interval breast cancer. Nippon Rinsho Geka Gakkai Zasshi.2017; 78: 935-941.

6.〔邦文雑誌〕N Takeda, Saori Koizumi, H Fuchikami, K Sato, Y Inoue. Evaluation of the association of menopausal status with tamoxifen treatment. Jpn J of Br Soc for Gyn./Obst. 2018 ; 1(1) :30-33

7.〔邦文雑誌〕H Seto, H Ota, T Hayashi, K Fujii, S Hori, R Matsuoka, N Takeda,H Fuchikami, K Sato. Efficacy of reviewed mammography in population-based breast cancer screening. Jpn J of Br Soc for Gyn./Obst. 2018 ; 1(1) :34-36

8.〔邦文雑誌〕N Takeda, H Fuchikami, Y Inoue, K Sato.Mammographic density affects breast cancer screening quality. J Jpn Assoc Breast Cancer Screen.2018; 27(2):173-177

9.〔邦文雑誌〕H Fuchikami, N Takeda, Y Suno, H Iijima, M Takaki, K Sato. Clinical significance and problems of percutaneous biopsy of liver metastasis in patients with breast cancer. Nippon Rinsho Geka Gakkai Zasshi.2020; 81(1): 14-19.

10.〔邦文雑誌〕N Takeda, H Fuchikami, Y Inoue, K Sato. Association between mammographic density and uterine fibroid in postmenopausal women. The Journal of Japan Society for Menopause and Women's Health. 2022; 29: 405-410.

11.〔邦文雑誌〕Sato K, Fuchikami H, Takeda N, Natsume N, Kato M.
Long-term efficacy and cosmetic outcomes of partial-breast irradiation using multicatheter interstitial brachytherapy
for breast-conserving therapy.
Nippon Rinsho Geka Gakkai Zasshi 2023 ; 84(2) 238-245.

12.〔邦文雑誌〕Sato K. Integration of AI-based risk assessment with intelligence bed management system to prevent falls. New Medicine in Japan (in press)

13.〔邦文雑誌〕N Takeda, H Fuchikami, Y Inoue, K Sato.Case of identical twins without BRCA mutation who developed breast cancer simultaneously. Jpn J of Br Soc for Gyn./Obst (in press)

14.〔英文雑誌〕H Takei, K Suemasu, K Inoue, T Saito, K Okubo, J Koh, K Sato, H Tsuda, M Kurosumi, T Tabei. Multicenter phase II trial of neoadjuvant exemestane for postmenopausal patients with hormone receptor-positive,operable breast cancer: Saitama Breast Cancer Clinical Study Group (SBCCSG-03). Breast Cancer Res Treat. 2008; 107:87-94

15.〔英文雑誌〕M Mukai, A Tanaka, T Tajima, M Fukasawa, T Yamagiwa, K Okada, K Sato, K Tobita, Y Oida, H Makuuchi. Two--port hand-assisted laparoscopic surgery for the 2-stage treatment of a complete bowel obstruction by left colon cancer: A case report. Oncology reports. 2008;19:875-879

16.〔英文雑誌〕Y Kikuchi, M Takano, K Kudoh, T Kita, K Sato. Successful treatment with weekly paclitaxel and carboplatin combined with trastuzumab in a patient with heavily pretreatmented metastatic breast cancer.European J of Ob/Gyn and Reproductive Biology. Brief Communication. 2008 Dec;141(2):189-91.

17.〔英文雑誌〕Tamaki Y, Akiyama F, Iwase T, Kaneko T, Tsuda H, Sato K, Ueda S,Mano M, Masuda N, Takeda M, Tsujimoto M, Yoshidome K, Inaji H,Nakajima H, Komoike Y, Kataoka TR, Nakamura S, Suzuki K, Tsugawa K,Wakasa K, Okino T, Kato Y, Noguchi S, Matsuura N.Molecular detection of lymph node metastases in breast cancer patients: results of a multicenter trial using the one-step nucleic acid amplification assay. Clin Cancer Res.2009 Apr 15;15(8):2879-84.

18.〔英文雑誌〕Kazuhiko Sato. Chemotherapy for breast cancer; present and perspectives.Chemotherapeutic Strategies for Gynecological Cancers, 2010: 123-129Transworld Research Network.

19.〔英文雑誌〕Kazuhiko Sato, Yoshio Mizuno, Masahiro Kato, Takahiro Shimo, Jun Kubota,Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa. IntraoperativeOpen-Cavity Implant for Accelerated Partial Breast Irradiation UsingHigh-Dose Rate Multicatheter Brachytherapy in Japanese Breast CancerPatients: A Single-Institution Registry Study. Journal of CancerTherapy, 2012, 3, 822-830.

20.〔英文雑誌〕Takeshita T, Tsuda H, Moriya T, Yamasaki T, Asakawa H, Ueda S, Sato K, Aida S, Tamai S, Matsubara O, Hase K, Yamamoto J. Clinical implications of occult metastases and isolated tumor cells in sentinel and non-sentinel lymph nodes in early breast cancer patients: serial step section analysis with long-term follow-up. Ann Surg Oncol. 2012;19(4):1160-6.

21.〔英文雑誌〕Yoshio Mizuno, Tsuneo Natori, Naoko Takeda, Junichi Yamada, Hiroaki Abe,Yuko Inoue, Hiroshi Seto, Kazuhiko Sato. The Reliability of Assessment of Ki-67 Expression on Core Needle Biopsy and the Surgical Specimens of Invasive Breast Cancer: Comparison of Local Pathologists’Assessment and Central Review. Journal of Cancer Therapy, 2012,3,841-845

22.〔英文雑誌〕Kazuhiko Sato, Yoshio Mizuno, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo, Jun Kubota, Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa. Individualized Case–Control Study of Accelerated Partial Breast Irradiation by Multicatheter Intertstitial Brachytherapy in Japanese Patients with Breast Cancer. Cancer and Clinical Oncology,2013,2,127-135

23.〔英文雑誌〕Kazuhiko Sato, Yoshio Mizuno, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo,Jun Kubota,Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa.Sentinel-Node-Driven Personalized Radiation Techniques Ranging from Partial Breast Irradiation to Regional Nodal Radiation after Breast-Conserving Surgery. Journal of Cancer Therapy, 2013,4,49-55

24.〔英文雑誌〕Sagara Y, Sato K, Fukuma E, Higaki K, Mizutani M, Osaki A, Takano T,Tokuda Y, Ohno S, Masuda N, Suzuki M, Saeki T. The Efficacy and Safety of FSK0808, Filgrastim Biosimilar: A Multicenter, Non-randomized Study in Japanese Patients with Breast Cancer. Jpn J Clin Oncol. 2013 Sep;43(9):865-73.

25.〔英文雑誌〕Yoshio Mizuno, Tsuneo Natori, Naoko Takeda, Junichi Yamada, Hiroaki Abe,Yuko Inoue, Hiroshi Seto, Kazuhiko Sato. Standardized Assessment of Ki-67 in Breast Cancer Patients Using Virtual Slides and an Automated Analyzer in Comparison to Central/Local Pathological Assessments.Journal of Cancer Therapy, 2014, 5,141-146.

26.〔英文雑誌〕Kazuhiko Sato, Yoshio Mizuno, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo,Jun Kubota,Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa.Single-institution comparison of accelerated partial breast irradiation and whole breast irradiation in breast cancer patients with unfavorable parameters by the American Society for Radiation Oncology guidelines.Journal of Tumor. 2014,2(6),129-133.

27.〔英文雑誌〕Kazuhiko Sato, Yoshio Mizuno, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo,Jun Kubota,Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa.Comparison of radiation dose to the left anterior descending artery by whole and partial breast irradiation in breast cancer patients. J Contemp Brachytherapy. 2015,7(1),23-28.

28.〔英文雑誌〕Kazuhiko Sato, Yoshio Mizuno, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo,Jun Kubota,Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa.Impact of young age on local control after partial breast irradiation in Japanese patients with early stage breast cancer. Breast Cancer.2017,24(1), 79–85. doi: 10.1007/s12282-016-0669-4.

29.〔英文雑誌〕Yoshio Mizuno, Hiromi Fuchikami, Naoko Takeda, Yuko Inoue, Hiroshi Seto, Kazuhiko Sato. Comparing Oncotype DX recurrence score categories with immunohistochemically defined luminal subtypes. Journal of Cancer Therapy, 2016,7,223-231.

30.〔英文雑誌〕Sato K. Commentary on the GEC-ESTRO trial: is partial breast irradiation ready for prime time? Transl Cancer Res 2016;5(S1):S107-S112 doi: 10.21037/tcr.2016.05.25

31.〔英文雑誌〕Y Mizuno, H Fuchikami,N Takeda,M Iwai,K Sato. Efficacy of reduced dose of pegfilgrastim in Japanese breast cancer patients receiving dose-dense doxorubicin and cyclophosphamide therapy. Jpn J Clin Oncol 2017; 47(1)12-17.

32.〔英文雑誌〕Iwai M, Sato K, Fuchikami H, Mizuno Y, Matsumoto H, Ikehara Y, Mase T, Kawamoto S, Shimoyama R, Shinozaki N. Controversies Regarding the Optimal Dose of Nab-paclitaxel Combined with Gemcitabine in a Phase 1 Trial of Patients with Metastatic Breast Cancer. Clin Oncol. 2016; 1: 1070.

33.〔英文雑誌〕Sato K, Fuchikami H, Takeda N, Iwai M. Therapeutic Option of Adding Bevacizumab to Paclitaxel after Treatment Failure for Patients withMetastatic Breast Cancer: Case Reports and Literature Review.Clin Surg. 2017; 2: 1306.

34.〔英文雑誌〕Kazuhiko Sato, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo,Jun Kubota,Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa.Efficacy of single-stage breast-conserving treatment using multicatheter partial-breast brachytherapy evaluated by GEC-ESTRO phase 3 trial.J Contemp Brachytherapy 2017; 9, 5: 424–430

35.〔英文雑誌〕Hiromi Fuchikami, Naoko Takeda, Kazuhiko Sato. Usefulness of Breast MRI for Safe Omission of Axillary Lymph Nodes Dissection in Sentinel Node-Positive Breast Cancer Patients.Journal of Cancer Therapy, 2017, 8, 1049-1057

36.〔英文雑誌〕Takano T, Tsurutani J, Takahashi M, Yamanaka T, Sakai K, Ito Y, Fukuoka J, Kimura H, Kawabata H, Tamura K, Matsumoto K, Aogi1 K, Sato K, Nishio K, Nakagawa K, Saeki T. A randomized phase II trial of trastuzumab plus capecitabine versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and taxanes: WJOG6110B/ELTOP. The Breast 2018, 40, 67-75.

37.〔英文雑誌〕Kazuhiko Sato, Hiromi Fuchikami, Naoko Takeda, Masahiro Kato, Takahiro Shimo, Tomohiko Okawa. alidating the efficacy of single-stage breast-conserving therapy using multicatheter partial-breast brachytherapy based on updated ASTRO Guidelines. Journal of Radiation Research, 2018,59(3),303-308.

38.〔英文雑誌〕Kazuhiko Sato, Takahiro Shimo, Hiromi Fuchikami, Naoko Takeda, Masahiro Kato, Tomohiko Okawa. Catheter-based delineation of lumpectomy cavity for accurate target definition in partial-breast irradiation with multicatheter interstitial Brachytherapy. J Contemp Brachytherapy2019 11(2), 108–115.

39.〔英文雑誌〕Kazuhiko Sato, Hiromi Fuchikami, Naoko Takeda, Masahiro Kato, Takahiro Shimo, Tomohiko Okawa. Moving incision for covert breast-conserving surgery may prevent early wound complications in brachytherapy-based partial-breast irradiation. Brachytherapy 2019 18, 645-650.

40.〔英文雑誌〕Tamura K, Imamura CK, Takano T, Saji S, Yamanaka T, Yonemori K, Takahashi M, Tsurutani J, Nishimura R, Sato K, Kitani A, Ueno NT, Mushiroda T, Kubo M, Fujiwara Y, Tanigawara Y. CYP2D6 Genotype-Guided Tamoxifen Dosing in Hormone Receptor-Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study. J Clin Oncol. 2020;38(6):558-566.

41.〔英文雑誌〕Sato K, Fuchikami H, Takeda N, Shimo T, Kato M, Okawa T. Efficacy of Single-Plane Implant Technique in Partial Breast Brachytherapy in Small-Breasted Patients. Int J Radiat Oncol Biol Phys. 2020;106(4):830-837.

42.〔英文雑誌〕 Matsumoto K, Takahashi M, Sato K, Osaki A, Takano T, Naito Y, Matsuura K, Aogi K, Fujiwara K, Tamura K, Baba M, Tokunaga S, Hirano G, Imoto S, Miyazaki C, Yanagihara K, Imamura C, Chiba Y, Saeki A. A double-blind, randomized, multicenter phase 3 study of palonosetron vs. granisetron combined with dexamethasone and fosaprepitant to prevent chemotherapy-induced nausea and vomiting in patients with breast cancer receiving anthracycline and cyclophosphamide. Cancer Med. 2020;9(10):3319-3327.

43.〔英文雑誌〕Sato K, Shimo T, Fuchikami H, Takeda N, Kato M, Okawa T. Predicting adherence of dose-volume constraints for personalized partial-breast irradiation technique. Brachytherapy 2021;20(1):163-170.

44.〔英文雑誌〕Sato K, Fuchikami H, Shimo T, Takeda N, Kato M, Okawa T.Preliminary report of partial-breast irradiation following neoadjuvant chemotherapy from COMBAT-NEO: Clinical Outcome of Multicatheter BrAchyTherapy after NEOadjuvant chemotherapy. Archives of Breast Cancer 2021;8(2):149-155.

45.〔英文雑誌〕Kazuhiko Sato, Takahiro Shimo, Masahiro Kato, MD, Nana Natsume, Hiromi Fuchikami, Naoko Takeda, Tomohiko Okawa.
Computed Tomography-guided Partial-breast Brachytherapy Using Implanted Catheters as Fiducial Markers versus Co-Registered Magnetic Resonance Imaging .Brachytherapy 2021;20(6):1219-1225.

46. 〔英文雑誌〕Sato K, Shimo T, Natsume N, Takeda N, Fuchikami H, Kato M, Okawa T. Impact of the delineation accuracy of lumpectomy cavity on planning target volume in partial-breast irradiation using brachytherapy and external-beam radiotherapy. Archives of Breast Cancer 2022;9(4): 456-64.

47. Sato K, Takeda N, Fuchikami H, Natsume N, Kato M, Okawa T.Impact of de-escalating systemic therapy guided by 21-gene assay on locoregional recurrence after partial-breast irradiation.Brachytherapy 2023;22(3):381-388.

48.Sato K, Fuchikami H, Takeda N,Natsume N, Kato M, Okawa T.Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheterinterstitial brachytherapyfor early-stage breast cancer. Breast Cancer (in press)

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